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Showing 1–2 of 2 results
Advanced filters: Author: Rojashree Jayakumar Clear advanced filters

  • This study identifies molecular pathogenesis in the kidney of myotonic dystrophy type 1 (DM1). The authors reveal downregulated metabolism genes in urinary extracellular vesicles (EVs) and kidney tissue, with elevated urine metabolites, suggesting urinary EVs as indicators of renal and metabolic disturbance.

    • Preeti Kumari
    • Lauren M. Sullivan
    • Thurman M. Wheeler
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Using single-nucleus RNA sequencing from 32 donors, researchers identified distinct astrocytic gene expression programs activated across brain regions and Alzheimer’s disease stages. They also found unique subclusters of astrocytes that appear to vary over time, highlighting the complexity of astrocytic responses in AD.

    • Alberto Serrano-Pozo
    • Huan Li
    • Sudeshna Das
    ResearchOpen Access
    Nature Neuroscience
    Volume: 27, P: 2384-2400