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Scientific Reports (6)
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Showing 1–20 of 20 results

Advanced filters: Author: Roland E Kontermann Clear advanced filters

Recombinant bispecific antibodies for cancer therapy

Roland E Kontermann
Reviews01 Jan 2005
Acta Pharmacologica Sinica

Volume: 26, P: 1-9
Complement recruitment using bispecific diabodies

Roland E. Kontermann
Mark G. Wing
Greg Winter
Research01 Jul 1997
Nature Biotechnology

Volume: 15, P: 629-631
BCL-xL as a therapeutic target in cetuximab-refractory colorectal cancer

Stella Asmanidou
Julia Thiel
Monilola A. Olayioye
ResearchOpen Access31 Jan 2026
Cell Death & Disease

Volume: 17, P: 1-14
Quantification of intratumoural heterogeneity in mice and patients via machine-learning models trained on PET–MRI data

Intratumoural heterogeneity can be characterized spatially in patients with liver metastases from colorectal cancer via phenotype-specific multi-view learning models trained with PET–MRI data from mice with subcutaneous colon tumours.

Prateek Katiyar
Johannes Schwenck
Jonathan A. Disselhorst
Research05 Jun 2023
Nature Biomedical Engineering

Volume: 7, P: 1014-1027
Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF

In humans, intrathymic development of DCs is evident but its physiological significance is unknown. Taghon et al. show intrathymic development of DCs as hematopoietic stromal support for the early stages of human T cell development via IRF8-driven transmembrane TNF.

Kai Ling Liang
Juliette Roels
Tom Taghon
Research26 Jan 2023
Nature Immunology

Volume: 24, P: 474-486
Comparison of antibody-scTRAIL Fc fusion proteins with varying valency for EGFR and TRAIL receptors

Dennis Michler
Oliver Seifert
Roland E. Kontermann
ResearchOpen Access06 May 2025
Scientific Reports

Volume: 15, P: 1-10
Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors

A targeting method for lentiviral vectors relying on the use of single-chain antibodies recognizing cell-surface antigens is applied to generate lentiviral vectors specific for endothelial cells, hematopoietic progenitors and neurons.

Brigitte Anliker
Tobias Abel
Christian J Buchholz
Research10 Oct 2010
Nature Methods

Volume: 7, P: 929-935
The present and future of bispecific antibodies for cancer therapy

Bispecific antibodies (bsAbs) can mediate therapeutic effects beyond those of natural monospecific antibodies. This Review provides an overview of recent developments in the field of bsAbs for cancer therapy and an outlook into next-generation bsAbs in earlier stages of development.

Christian Klein
Ulrich Brinkmann
Roland E. Kontermann
Reviews06 Mar 2024
Nature Reviews Drug Discovery

Volume: 23, P: 301-319
A scDb-based trivalent bispecific antibody for T-cell-mediated killing of HER3-expressing cancer cells

Nadine Aschmoneit
Sophia Steinlein
Roland E. Kontermann
ResearchOpen Access06 Jul 2021
Scientific Reports

Volume: 11, P: 1-12
IgG-single-chain TRAIL fusion proteins for tumour therapy

Martin Siegemund
Felix Schneider
Roland E. Kontermann
ResearchOpen Access17 May 2018
Scientific Reports

Volume: 8, P: 1-11
Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2

Roman Fischer
Jessica Marsal
Roland E. Kontermann
ResearchOpen Access26 Jul 2017
Scientific Reports

Volume: 7, P: 1-13
The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration

Natalia Ortí-Casañ
Ate S. Boerema
Ulrich L. M. Eisel
ResearchOpen Access30 Jun 2023
Scientific Reports

Volume: 13, P: 1-13
Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids

Daniela Stöhr
Jens O. Schmid
Markus Rehm
ResearchOpen Access20 May 2020
Cell Death & Differentiation

Volume: 27, P: 3037-3052
Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma

Greta Del Mistro
Shamala Riemann
Dagmar Kulms
ResearchOpen Access12 Jan 2022
Cell Death & Disease

Volume: 13, P: 1-15
Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma

Greta Del Mistro
Philippe Lucarelli
Dagmar Kulms
ResearchOpen Access05 Nov 2018
npj Systems Biology and Applications

Volume: 4, P: 1-12
Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis

Sarah K. Williams
Richard Fairless
Ricarda Diem
ResearchOpen Access11 Sept 2018
Scientific Reports

Volume: 8, P: 1-14
Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism

Vesna Vetma
Cristiano Guttà
Markus Rehm
ResearchOpen Access21 Feb 2020
Cell Death & Differentiation

Volume: 27, P: 2417-2432
Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism

Frank A. Lincoln
Dirke Imig
Markus Rehm
ResearchOpen Access01 Nov 2018
Cell Death & Disease

Volume: 9, P: 1-14
TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice

Franziska Wandrer
Stephanie Liebig
Heike Bantel
ResearchOpen Access31 Mar 2020
Cell Death & Disease

Volume: 11, P: 1-9
Inhibition of cell proliferation and induction of apoptosis by novel tetravalent peptides inhibiting DNA binding of E2F

Silvia Montigiani
Rolf Müller
Roland E Kontermann
Research06 Aug 2003
Oncogene

Volume: 22, P: 4943-4952