One of the major challenges of metastasis research is being able to track the fate of individual metastasizing cancer cells over time. Here, Kienast et al. describe an animal model in which multiphoton laser scanning microscopy is used to image the steps involved in the establishment of brain metastasis in vivo. The movement of systemically injected, red fluorescent protein–labeled tumor cells is monitored over several weeks, revealing potential targets for therapy.
- Yvonne Kienast
- Louisa von Baumgarten
- Frank Winkler
