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Showing 1–4 of 4 results
Advanced filters: Author: Romain Ballet Clear advanced filters

  • Chronic brain infection and IL-1 exposure impair spatial memory by triggering DNA double-strand break signaling in hippocampal neurons. Blocking this pathway prevents memory deficits, suggesting new therapeutic prospects for various brain diseases.

    • Marcy Belloy
    • Benjamin A. M. Schmitt
    • Elsa Suberbielle
    Research
    Nature Neuroscience
    Volume: 28, P: 2067-2077

  • Lymphocyte homing to the gut and Peyer’s patches requires expression of integrin α4β7. Ballet and colleagues report that B cell expression of CD22 is required to specifically retain surface expression of β7 integrin molecules, thereby promoting B cell retention in the gut and optimal gut mucosal antibody responses.

    • Romain Ballet
    • Martin Brennan
    • Eugene C. Butcher
    Research
    Nature Immunology
    Volume: 22, P: 381-390

  • Il-10-expressing B cells play a pivotal role in immune homeostasis, but little is known about the factors and pathways that affect the development of this heterologous population of regulatory B cells. Here authors show in a mouse model that in embryonic life, soluble IgM restrains the expansion of Il-10-positive B cells, via utilizing FcµR and other putative receptors.

    • Shannon Eileen McGettigan
    • Lazaro Emilio Aira
    • Gudrun F. Debes
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Thymic epithelial cells provide the microenvironment required for the expansion of T cells in the thymus, but their exact function is not well understood. Here, the authors report that thymic epithelial cells are the source of matricellular protein CYR61, which is involved in thymic function and T cell development.

    • Yalin Emre
    • Magali Irla
    • Beat A. Imhof
    Research
    Nature Communications
    Volume: 4, P: 1-11