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The role of diet and exercise in the transgenerational epigenetic landscape of T2DM

In this Review, Romain Barrès and Juleen Zierath outline the current understanding of the mechanisms underlying how lifestyle factors affect epigenetic changes involved in the risk of type 2 diabetes mellitus. The latest findings on the mechanisms by which diet and exercise affect the epigenome are also discussed.

Romain Barrès
Juleen R. Zierath
Reviews17 Jun 2016
Nature Reviews Endocrinology

Volume: 12, P: 441-451
Paternal dietary macronutrient balance and energy intake drive metabolic and behavioral differences among offspring

The dietary factors causing varying intergenerational responses are not fully identified. Here, the authors show that the relative proportion of protein, fats, and carbohydrates in paternal diets before conception differentially influences the phenotype of the next-generation offspring on energy metabolism and behaviour.

Angela Jane Crean
Alistair McNair Senior
Stephen James Simpson
ResearchOpen Access06 Apr 2024
Nature Communications

Volume: 15, P: 1-11
Exposure to childhood maltreatment is associated with specific epigenetic patterns in sperm

Jetro J. Tuulari
Matthieu Bourgery
Noora Kotaja
ResearchOpen Access03 Jan 2025
Molecular Psychiatry

Volume: 30, P: 2635-2644
Author Correction: Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

Leonidas S. Lundell
Evelyn B. Parr
John A. Hawley
Amendments and CorrectionsOpen Access08 Oct 2020
Nature Communications

Volume: 11, P: 1
Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism

Exercise induces structural and functional adaptations in skeletal muscle that involve transcriptomic remodeling, including of miRNA expression. Here the authors examine the expression of miRNAs in human muscle following exercise training and investigate the functions of miR-19b-3p on glucose metabolism in cells and mouse muscle.

Julie Massart
Rasmus J. O. Sjögren
Anna Krook
ResearchOpen Access12 Oct 2021
Nature Communications

Volume: 12, P: 1-13
Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

Time restricted feeding has several health benefits. Here the authors perform a randomised cross-over study with 11 men with overweight/obesity to investigate how time restricted feeding affects skeletal muscle and serum, and report that it does not affect the core circadian machinery, but modifies periodicity in amino acid related metabolites and transporters.

Leonidas S. Lundell
Evelyn B. Parr
John A. Hawley
ResearchOpen Access16 Sept 2020
Nature Communications

Volume: 11, P: 1-11
Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

Obesity and type 2 diabetes (T2D) are metabolic disorders characterized by insulin resistance in skeletal muscle. Here, the authors map skeletal muscle enhancer elements dynamically regulated after exposure to free fatty acid palmitate or inflammatory cytokine TNFα and identify target genes involved in metabolic dysfunction in skeletal muscle.

Kristine Williams
Lars R. Ingerslev
Romain Barrès
ResearchOpen Access01 Jun 2020
Nature Communications

Volume: 11, P: 1-16
Dietary macronutrient composition impacts gene regulation in adipose tissue

A Nutritional Geometry study in mice identifies complex gene regulatory responses to differences in dietary macronutrient contribution including differential splicing of thousands of genes, most of which did not undergo gene expression changes.

Kathryn M. Farris
Alistair M. Senior
Marcelo A. Nobrega
ResearchOpen Access16 Feb 2024
Communications Biology

Volume: 7, P: 1-13
Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding

Adriana Ibarra Urizar
Michala Prause
Nils Billestrup
ResearchOpen Access05 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-16
Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans

Anna Borup
Ida Donkin
Christina Christoffersen
ResearchOpen Access05 Nov 2022
Scientific Reports

Volume: 12, P: 1-11
Cold-induction of afadin in brown fat supports its thermogenic capacity

Morten Lundh
Ali Altıntaş
Brice Emanuelli
ResearchOpen Access07 May 2021
Scientific Reports

Volume: 11, P: 1-11
Insulin resistance rewires the metabolic gene program and glucose utilization in human white adipocytes

Marie S. Isidor
Wentao Dong
Brice Emanuelli
Research19 Nov 2021
International Journal of Obesity

Volume: 46, P: 535-543
Preadipocytes from obese humans with type 2 diabetes are epigenetically reprogrammed at genes controlling adipose tissue function

Emil Andersen
Lars Roed Ingerslev
Romain Barrès
Research20 Feb 2018
International Journal of Obesity

Volume: 43, P: 306-318

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