Errors during pancreas development and specification of the endocrine lineage can result in severe neonatal diabetes. Here they show that loss of NEUROD1 leads to disturbances in endocrine cell identity acquisition during pancreas development, with cellular reprogramming occurring at the single-cell level within both α- and β-cell populations.
- Romana Bohuslavova
- Valeria Fabriciova
- Gabriela Pavlinkova
