Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Romulo J. C. Albuquerque Clear advanced filters

  • A geographically diverse group of 29 ethnobiologists addresses three common themes in response to the COVID-19 global health crisis: impact on local communities, future interactions between researchers and communities, and new (or renewed) conceptual and/or applied research priorities for ethnobiology.

    • Ina Vandebroek
    • Andrea Pieroni
    • Farid Dahdouh-Guebas
    Reviews
    Nature Plants
    Volume: 6, P: 723-730

  • Although endogenous inhibitors of blood vessel growth have been studied extensively, specific inhibitors of lymphatic vessel growth have not been identified. Albuquerque et al. now identify truncated, secreted versions of mouse and human VEGFR-2 receptors generated by alternative splicing. The mouse protein acts as an endogenous inhibitor of lymphatic vessel growth in the cornea and skin, and its administration had therapeutic effects in mouse models of corneal injury and transplantation.

    • Romulo J C Albuquerque
    • Takahiko Hayashi
    • Jayakrishna Ambati
    Research
    Nature Medicine
    Volume: 15, P: 1023-1030

  • Age-related macular degeneration (AMD) is a major cause of blindness. Now, the eosinophil/mast cell chemokine receptor CCR3 is shown to be specifically expressed in choroidal neovascular endothelial cells in humans with AMD, and targeting CCR3 or its ligands in mice inhibits the choroidal neovascularization that underlies AMD. In the mouse model, CCR3 blockade was more effective and less toxic than VEGF-A neutralization, which is currently in clinical use.

    • Atsunobu Takeda
    • Judit Z. Baffi
    • Jayakrishna Ambati
    Research
    Nature
    Volume: 460, P: 225-230

  • In geographic atrophy, a type of macular degeneration, retinal pigmented epithelium (RPE) cells die. This paper finds that DICER1, which processes miRNA precursors, is reduced in RPE from individuals with geographic atrophy. Cell death is not due to loss of miRNA processing, however; rather, the absence of DICER1 allows accumulation of pathological Alu repeat sequence RNAs. This work reveals a novel function of Dicer in degrading Alu RNAs.

    • Hiroki Kaneko
    • Sami Dridi
    • Jayakrishna Ambati
    Research
    Nature
    Volume: 471, P: 325-330

  • The antiangiogenic effect of siRNAs does not depend on the target of the siRNA, or on intraocular administration. Rather, the siRNAs activate TLR3, a cell surface receptor for long viral dsRNAs, and innate immunity.

    • Mark E. Kleinman
    • Kiyoshi Yamada
    • Jayakrishna Ambati
    Research
    Nature
    Volume: 452, P: 591-597