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Showing 1–3 of 3 results
Advanced filters: Author: Ron Winograd Clear advanced filters

  • This Case Study describes a 24-year-old white male with Crohn's disease that was in remission who presented with cholestasis and hyperbilirubinemia. The patient had normal alanine aminotrasferase and γ-globulin levels, and the results of serological tests for an infectious cause of hepatopathia were negative. The patient was diagnosed with autoimmune hepatitis–primary sclerosing cholangitis overlap syndrome on the background of primary sclerosing cholangitis.

    • Leif E Sander
    • Alexander Koch
    • Andreas Geier
    Reviews
    Nature Clinical Practice Gastroenterology & Hepatology
    Volume: 4, P: 635-640

  • Yardena Samuels and colleagues report the analysis of 501 melanoma exomes and the identification of RASA2 as a tumor-suppressor gene mutated in 5% of melanomas. RASA2 mutations led to increased RAS activation, and RASA2 loss was associated with shorter patient survival times.

    • Rand Arafeh
    • Nouar Qutob
    • Yardena Samuels
    Research
    Nature Genetics
    Volume: 47, P: 1408-1410

  • Correct Golgi assembly is important to cellular homeostasis but regulation of its structure under stress remains unclear. Here, the authors identify stress-induced degradation of GM130 by Golgi-localized 26S proteasomes, leading to Golgi dispersal.

    • Avital Eisenberg-Lerner
    • Ron Benyair
    • Yifat Merbl
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14