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Showing 1–9 of 9 results
Advanced filters: Author: Ronald A Conlon Clear advanced filters

  • The mechanisms behind the oncogenic role of the PIK3CA helical domain mutant is poorly understood. Here, the authors show that its oncogenic function depends on the release of p85β from mutated p110α, its translocation to the nucleus and the consequent increased activity of EZH proteins.

    • Yujun Hao
    • Baoyu He
    • Zhenghe Wang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • In a mouse model of the leukodystrophy Pelizaeus–Merzbacher disease, myelination, motor performance, respiratory function and lifespan are improved by suppressing proteolipid protein expression, suggesting PLP1 as a therapeutic target for human patients with this disease and, more broadly, antisense oligonucleotides as a pharmaceutical modality for treatment of myelin disorders.

    • Matthew S. Elitt
    • Lilianne Barbar
    • Paul J. Tesar
    Research
    Nature
    Volume: 585, P: 397-403

  • Mutations in the Wnt co-receptor, LRP5, lead to skeletal diseases in humans. Matthew Warman and his colleagues have now developed mutant mice with tissue-specific alterations of Lrp5 expression and found that these mice phenocopy the human skeletal diseases. They also found that Lrp5 acts locally to affect bone homeostasis. Their data suggest that increasing LRP5 signaling in mature bone cells may be a strategy to treat osteoporosis.

    • Yajun Cui
    • Paul J Niziolek
    • Alexander G Robling
    Research
    Nature Medicine
    Volume: 17, P: 684-691

  • Cancer cells rely on glutamine to replenish the TCA cycle. Here, the authors show that oncogenic PIK3CAmutations drive this metabolic rewiring in colorectal cancer cells by up-regulating glutamate pyruvate transaminase expression, thus increasing sensitivity to glutamine starvation.

    • Yujun Hao
    • Yardena Samuels
    • Zhenghe Wang
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Interleukin-17 (IL-17)-secreting CD4 T cells (Th17) are induced by the master transcription factor RORγt, and are important for anti-fungal immunity and inflammatory responses. Here the authors show that Ubc9-mediated SUMOylation of RORγt induces HDAC2 binding to IL-17 promoter for suppressing IL-17 production in Th17 cells.

    • Amir Kumar Singh
    • Prashant Khare
    • K. Venuprasad
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11