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Correction: Corrigendum: Classification and characterization of microsatellite instability across 18 cancer types

Ronald J Hause
Colin C Pritchard
Stephen J Salipante
Amendments and Corrections01 Apr 2018
Nature Medicine

Volume: 24, P: 525
Correction: Corrigendum: Classification and characterization of microsatellite instability across 18 cancer types

Ronald J Hause
Colin C Pritchard
Stephen J Salipante
Amendments and Corrections01 Oct 2017
Nature Medicine

Volume: 23, P: 1241
Multiplex assessment of protein variant abundance by massively parallel sequencing

VAMP-seq is a scalable assay that measures the effects of missense variants on intracellular protein abundance. Applying VAMP-seq to thousands of PTEN and TPMT variants helps to classify them as pathogenic or benign.

Kenneth A. Matreyek
Lea M. Starita
Douglas M. Fowler
Research21 May 2018
Nature Genetics

Volume: 50, P: 874-882
Saturation editing of genomic regions by multiplex homology-directed repair

The authors perform saturation mutagenesis of genomic regions in their native endogenous chromosomal context by using CRISPR/Cas9 RNA-guided cleavage and multiplex homology-directed repair; its utility is demonstrated by measuring the effects of hundreds to thousands of genomic edits to BRCA1 and DBR1 on splicing and cellular fitness, respectively.

Gregory M. Findlay
Evan A. Boyle
Jay Shendure
Research03 Sept 2014
Nature

Volume: 513, P: 120-123
Classification and characterization of microsatellite instability across 18 cancer types

Systematic analysis of more than 5,900 human tumor exomes yields a new genomic classifier of microsatellite instability and insight into its prevalence and biological implications.

Ronald J Hause
Colin C Pritchard
Stephen J Salipante
Research03 Oct 2016
Nature Medicine

Volume: 22, P: 1342-1350
Mapping 3D genome architecture through in situ DNase Hi-C

Ramani et al. describe a protocol for in situ DNase Hi-C as an alternative to traditional Hi-C methods that use restriction enzymes. The use of DNase I for chromatin digestion circumvents the resolution limit imposed when relying on genomic restriction sites.

Vijay Ramani
Darren A Cusanovich
Zhijun Duan
Protocols29 Sept 2016
Nature Protocols

Volume: 11, P: 2104-2121

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Correction: Corrigendum: Classification and characterization of microsatellite instability across 18 cancer types

Correction: Corrigendum: Classification and characterization of microsatellite instability across 18 cancer types

Multiplex assessment of protein variant abundance by massively parallel sequencing

Saturation editing of genomic regions by multiplex homology-directed repair

Classification and characterization of microsatellite instability across 18 cancer types

Mapping 3D genome architecture through in situ DNase Hi-C

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