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Showing 1–5 of 5 results
Advanced filters: Author: Ronald S. Flannagan Clear advanced filters

  • A potent inhibitor of the MRSA virulence regulator, GraR, reverses methicillin resistance, inhibits biofilm formation, limits bacterial survival in macrophages and attenuates virulence in vitro, synergizing with cationic antimicrobial peptides.

    • Omar M. El-Halfawy
    • Tomasz L. Czarny
    • Eric D. Brown
    Research
    Nature Chemical Biology
    Volume: 16, P: 143-149

  • Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD), underscoring the power of the presented analysis to minimize false assignments of disease risk.

    • Sanna Gudmundsson
    • Moriel Singer-Berk
    • Anne O’Donnell-Luria
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • The host cell and intracellular pathogens are in a continuous struggle. Flannagan, Cosío and Grinstein describe the pathway by which the bacteria are taken up, the antimicrobial mechanisms of the host cell and the different ways bacteria evade these mechanisms.

    • Ronald S. Flannagan
    • Gabriela Cosío
    • Sergio Grinstein
    Reviews
    Nature Reviews Microbiology
    Volume: 7, P: 355-366

  • PurR acts as transcriptional repressor of purine biosynthesis genes in some bacterial species. Here, the authors show that purR mutations can arise in Staphylococcus aureus upon exposure to stress, leading to upregulation of fibronectin-binding proteins and increased virulence.

    • Mariya I. Goncheva
    • Ronald S. Flannagan
    • David E. Heinrichs
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Coagulase-negative staphylococci and Staphylococcus aureus colonize similar niches in mammals. Here, Chin et al. show that a coagulase-negative staphylococcus secretes 6-thioguanine, a purine analog that suppresses S. aureus growth and virulence by inhibiting de novo purine biosynthesis and toxin production.

    • Denny Chin
    • Mariya I. Goncheva
    • David E. Heinrichs
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12