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Showing 1–3 of 3 results
Advanced filters: Author: Ronan Bergin Clear advanced filters

  • The NLRP3 inflammasome is important for inducing IL-1β and IL-18 inflammatory responses. Here the authors show, by generating and characterizing Peli2 deficient mice and immune cells, that an E3 ubiquitin ligase Pellino2 promotes inflammasome priming by inducing NLRP3 ubiquitination and by targeting IRAK1.

    • Fiachra Humphries
    • Ronan Bergin
    • Paul N. Moynagh
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • Toll-like receptors detect conserved microbial features to initiate host defence and are tightly regulated. Here the authors show that the orphan receptor interleukin-17 receptor D negatively regulates signalling downstream of Toll-like receptors to prevent excessive inflammation.

    • Mark Mellett
    • Paola Atzei
    • Paul N. Moynagh
    Research
    Nature Communications
    Volume: 6, P: 1-15