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Direct allylic acylation via cross-coupling involving cooperative N‑heterocyclic carbene, hydrogen atom transfer, and photoredox catalysis

The versatility and importance of β,γ-unsaturated ketones has been appreciated for a long time in synthesis and medicinal chemistry. Here, the authors use carboxylic acids and readily available olefins as substrates for transformations involving N‑heterocyclic carbene catalysis, hydrogen atom transfer catalysis, and photoredox catalysis for the synthesis of β,γ-unsaturated ketones.

Xiaochen Wang
Rongxin Yang
Qingmin Wang
ResearchOpen Access23 May 2023
Nature Communications

Volume: 14, P: 1-10
Structural insights into H⁺-coupled multidrug extrusion by a MATE transporter

Bacterial multidrug efflux transporters (MATEs) couple drug export to Na⁺ or H⁺ influx. A new crystal structure of the H⁺-coupled DinF transporter from Bacillus halodurans reveals differences in the substrate-binding sites and transport mechanisms of DinF and NorM MATE homologs.

Min Lu
Martha Radchenko
Yi Guo
Research20 Oct 2013
Nature Structural & Molecular Biology

Volume: 20, P: 1310-1317
Structural basis for the blockade of MATE multidrug efflux pumps

MATE transporters confer bacterial multidrug resistance by transporting drugs across cell membranes. Here, the authors present new structures of the DinF and NorM MATE transporters and reveal insights into the mechanisms of substrate transport and MATE inhibition by small-molecule pharmaceuticals.

Martha Radchenko
Jindrich Symersky
Min Lu
ResearchOpen Access06 Aug 2015
Nature Communications

Volume: 6, P: 1-11
Automated and collision-free navigation of multiple micro-objects in obstacle-dense microenvironments using optoelectronic tweezers

Lixiang Zheng
Gong Li
Yu Sun
ResearchOpen Access17 Mar 2025
Microsystems & Nanoengineering

Volume: 11, P: 1-13
Cell pyroptosis in health and inflammatory diseases

Yongqi Wu
Jing Zhang
Rongxin Zhang
ResearchOpen Access11 Apr 2022
Cell Death Discovery

Volume: 8, P: 1-8
Deciphering the mechanisms of long non-coding RNAs in ferroptosis: insights into its clinical significance in cancer progression and immunology

Shengming Ou
Xiaoya Nie
Jinrong Zhu
ReviewsOpen Access18 Jan 2025
Cell Death Discovery

Volume: 11, P: 1-10
Geoelectric field response characteristics analysis of floor roadway surrounding rock fracture caused due to coal seam mining

Yuanchao Ou
Pingsong Zhang
Lei Tan
ResearchOpen Access16 Nov 2021
Scientific Reports

Volume: 11, P: 1-15
fM to aM nucleic acid amplification for molecular diagnostics in a non-stick-coated metal microfluidic bioreactor

Guoliang Huang
Qin Huang
Jiancheng Ye
ResearchOpen Access05 Dec 2014
Scientific Reports

Volume: 4, P: 1-9
Optical trapping of mesoscale particles and atoms in hollow-core optical fibers: principle and applications

Rui Wang
Wei Li
Shangran Xie
ReviewsOpen Access31 Mar 2025
Light: Science & Applications

Volume: 14, P: 1-23

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