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Showing 1–2 of 2 results
Advanced filters: Author: Ronja Mülfarth Clear advanced filters

  • Taylor et al. show that tumor cells promote white adipose tissue (WAT) wasting and cachexia by overactivation of Notch1 signaling and retinoic acid production in distant WAT endothelium, which can be therapeutically targeted to inhibit wasting.

    • Jacqueline Taylor
    • Leonie Uhl
    • Andreas Fischer
    ResearchOpen Access
    Nature Cancer
    Volume: 4, P: 1544-1560

  • The presence of peritoneal metastasis in pancreatic cancers is associated with poor prognosis. Here the authors show that hyaluronan and proteoglycan link protein-1 (HAPLN1) promotes tumour cell plasticity and pro-tumoral immune microenvironment to facilitate peritoneal dissemination in pancreatic cancers.

    • Lena Wiedmann
    • Francesca De Angelis Rigotti
    • Juan Rodriguez-Vita
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18