The authors optogenetically suppressed CA1 pyramidal neurons during awake sharp-wave ripples (SPW-R) as mice were learning reward locations in a multiwell maze. Comparison of place cells’ activities before and after SPW-R manipulation suggests that interference with SPW-R-associated activity during learning prevents stabilization and refinement of the hippocampal map.
- Lisa Roux
- Bo Hu
- György Buzsáki
