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Advanced filters: Author: Rony Chidiac Clear advanced filters

Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils

Genome-wide CRISPR/Cas9 screening reveals novel modulators of heparan sulfate proteoglycans that regulate cellular uptake of α-synuclein fibrils, including in human dopaminergic neurons.

Benoît Vanderperre
Amitha Muraleedharan
Edward A. Fon
ResearchOpen Access06 Oct 2025
Communications Biology

Volume: 8, P: 1-24
ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis

ZO-1, a cell junction protein, is essential for angiogenesis. Here the authors identify in endothelial cells unexpected associations of ZO-1 with stress granule proteins, such as YB-1, that are crucial for cytoprotection, implicating the ZO-1-YB-1 interaction in angiogenesis.

Yassine El Bakkouri
Rony Chidiac
Jean-Philippe Gratton
ResearchOpen Access23 May 2024
Nature Communications

Volume: 15, P: 1-19
AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network

AXL receptor tyrosine kinase has a role in metastasis but the mechanism is unclear. In this study, the authors show that AXL activation can control focal adhesion dynamics via PEAK1 and that AXL-mediated PEAK1 phosphorylation is required for metastasis of triple negative breast cancer cells in vivo.

Afnan Abu-Thuraia
Marie-Anne Goyette
Jean-François Côté
ResearchOpen Access17 Jul 2020
Nature Communications

Volume: 11, P: 1-20

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