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Showing 1–4 of 4 results
Advanced filters: Author: Rosalie P. C. Driessen Clear advanced filters

  • How the genome is physically organized is less understood in archaea than in eubacteria or eukaryotes. Laurens et al. measure DNA binding by the Sulfolobus solfataricusproteins Alba1 and Alba2 using single-molecule techniques and conclude that the presence of Alba2 leads to more bridging between DNA.

    • Niels Laurens
    • Rosalie P.C. Driessen
    • Gijs J.L. Wuite
    ResearchOpen Access
    Nature Communications
    Volume: 3, P: 1-8

  • The archaeal genome is organized by either eukaryotic-like histone proteins or bacterial-like architectural proteins. Dame and colleagues discuss the interplay between chromatin proteins and components of the basal and regulatory transcription machinery, and describe how these factors cooperate in nucleoid structuring and gene regulation.

    • Eveline Peeters
    • Rosalie P. C. Driessen
    • Remus T. Dame
    Reviews
    Nature Reviews Microbiology
    Volume: 13, P: 333-341

  • Mechanical distortion of DNA structure induces off-target binding and cleavage by SpyCas9 at sites with up to ten mismatches, a potential mechanism that exposes cryptic off-target sites in cells during transcription or replication.

    • Matthew D. Newton
    • Benjamin J. Taylor
    • David S. Rueda
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 185-192