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Advanced filters: Author: Rosalie S. deBeaumont Clear advanced filters

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

A subunit of the ARC/Mediator co-activator complex is a key effector of the SREBP transcription factor during regulation of lipid homeostasis in human cells and Caenorhabditis elegans. The SREBP activation domain directly targets a KIX domain on ARC105/MED15

Fajun Yang
Bryan W. Vought
Anders M. Näär
Research21 Jun 2006
Nature

Volume: 442, P: 700-704
Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss

RNA editing enzyme ADAR1 is a therapeutic vulnerability in tumors with constitutive cell-autonomous production of interferon-stimulated genes

Huayang Liu
Javad Golji
E. Robert McDonald III
Research17 Dec 2018
Nature Medicine

Volume: 25, P: 95-102

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An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss

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