Nature Search

Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

In patients with advanced melanoma, fecal microbiota transplantation from healthy donors combined with the anti-PD-1 inhibitors nivolumab or pembrolizumab was well tolerated with an encouraging objective response rate of 65% in the first-line treatment setting.

Bertrand Routy
John G. Lenehan
Saman Maleki Vareki
Research06 Jul 2023
Nature Medicine

Volume: 29, P: 2121-2132
Post-translational insertion of boron in proteins to probe and modulate function

Post-translational site-selective formation of boronoalanine in proteins enables applications of boron for binding partner capture, footprinting of interactions with reactive oxygen species, proteolytic control and mapping of transient structures.

Tim A. Mollner
Patrick G. Isenegger
Benjamin G. Davis
ResearchOpen Access01 Nov 2021
Nature Chemical Biology

Volume: 17, P: 1245-1261
Identification and characterization of two functional variants in the human longevity gene FOXO3

FOXO3 is one of the few established longevity genes. Here, the authors fine-map the FOXO3-longevity association to two intronic SNPs and, using luciferase assays and EMSAs, show that these SNPs affect binding of transcription factors CTCF and SRF and associate with FOXO3 expression.

Friederike Flachsbart
Janina Dose
Almut Nebel
ResearchOpen Access12 Dec 2017
Nature Communications

Volume: 8, P: 1-12
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

Robert Graham and colleagues report results of a large-scale replication study for systemic lupus erythematosus (SLE) in individuals of European ancestry. Their findings expand the number of confirmed SLE susceptibility loci and implicate several key immunologic pathways in SLE pathogenesis.

Vesela Gateva
Johanna K Sandling
Robert R Graham
Research18 Oct 2009
Nature Genetics

Volume: 41, P: 1228-1233
Retraction Note: Complex societies precede moralizing gods throughout world history

Harvey Whitehouse
Pieter François
Peter Turchin
Amendments and Corrections07 Jul 2021
Nature

Volume: 595, P: 320
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14

Clare Turnbull and colleagues identify nine new susceptibility loci for testicular germ-cell tumor. The newly identified risk regions include variants near DAZL and PRDM14, genes known to be important for germ cell development.

Elise Ruark
Sheila Seal
Clare Turnbull
Research12 May 2013
Nature Genetics

Volume: 45, P: 686-689
Complement genes contribute sex-biased vulnerability in diverse disorders

Sexual dimorphism in genetic vulnerability to schizophrenia, systemic lupus erythematosus and Sjögren’s syndrome is linked to differential protein abundance from alleles of complement component 4.

Nolan Kamitaki
Aswin Sekar
Steven A. McCarroll
Research11 May 2020
Nature

Volume: 582, P: 577-581
RETRACTED ARTICLE: Complex societies precede moralizing gods throughout world history

Belief in moralizing gods followed the expansion of human societies and may have been preceded by doctrinal rituals that contributed to the initial rise of social complexity.

Harvey Whitehouse
Pieter François
Peter Turchin
Research20 Mar 2019
Nature

Volume: 568, P: 226-229
A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE

Johanna K Sandling
Sophie Garnier
Ann-Christine Syvänen
ResearchOpen Access22 Dec 2010
European Journal of Human Genetics

Volume: 19, P: 479-484
Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium

Artitaya Lophatananon
Sarah Stewart-Brown
Kenneth Muir
ResearchOpen Access01 Aug 2017
British Journal of Cancer

Volume: 117, P: 734-743
Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress

S Prabakaran
J E Swatton
S Bahn
Research20 Apr 2004
Molecular Psychiatry

Volume: 9, P: 684-697

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Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Post-translational insertion of boron in proteins to probe and modulate function

Identification and characterization of two functional variants in the human longevity gene FOXO3

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

Retraction Note: Complex societies precede moralizing gods throughout world history

Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14

Complement genes contribute sex-biased vulnerability in diverse disorders

RETRACTED ARTICLE: Complex societies precede moralizing gods throughout world history

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE

Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium

Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress

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