Nature Search

Chemosensor receptors are lipid-detecting regulators of macrophage function in cancer

Tumor-associated macrophages are pivotal in control over solid tumors. Here the authors show that these macrophages express chemosensors that detect lipid variants in the tumor microenvironment that can regulate the function of these cells.

Giulia Marelli
Nicolò Morina
Diletta Di Mitri
ResearchOpen Access30 Jun 2025
Nature Immunology

Volume: 26, P: 1182-1197
An Asn > Lys substitution in saposin B involving a conserved amino acidic residue and leading to the loss of the single N-glycosylation site in a patient with metachromatic leukodystrophy and normal arylsulphatase A activity

Stefano Regis
Mirella Filocamo
Rosanna Gatti
Research30 Mar 1999
European Journal of Human Genetics

Volume: 7, P: 125-130
Increased ectodysplasin-A2-receptor EDA2R is a ubiquitous hallmark of aging and mediates parainflammatory responses

In a broad cross-tissue analysis, the authors show that a receptor called EDA2R steadily increases with age in both humans and animal models, and becomes even more active in conditions like obesity and diabetes, intensifying inflammation-like processes in muscle cells.

Maria Chiara Barbera
Luca Guarrera
Marco Bolis
ResearchOpen Access23 Feb 2025
Nature Communications

Volume: 16, P: 1-11
Disruption of insulin–like growth factor 2 imprinting in Beckwith–Wiedemann syndrome

Rosanna Weksberg
Ding Ren Shen
Jeremy Squire
Research01 Oct 1993
Nature Genetics

Volume: 5, P: 143-150
Expression of cyclin D1 correlates with malignancy in human ovarian tumours

F Barbieri
M Cagnoli
A Alama
Research01 May 1997
British Journal of Cancer

Volume: 75, P: 1263-1268
ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97

VCP/p97 is identified as a co-factor to the fusion oncoprotein ASPSCR1::TFE3. They co-localize on chromatin, co-dependent for enhancer looping and transcriptional regulation in alveolar soft part sarcomas and Xp11- rearranged renal cell carcinomas.

Amir Pozner
Li Li
Kevin B. Jones
ResearchOpen Access07 Feb 2024
Nature Communications

Volume: 15, P: 1-21
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

Genome-wide association analyses identify 30 risk loci for IgA nephropathy. Functional annotations of putative causal genes converge on inflammatory signaling pathways and cytokine ligand–receptor pairs, prioritizing potential new drug targets.

Krzysztof Kiryluk
Elena Sanchez-Rodriguez
Ali G. Gharavi
Research19 Jun 2023
Nature Genetics

Volume: 55, P: 1091-1105
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Computationally guided high-throughput design of self-assembling drug nanoparticles

Self-assembly of small drugs with organic dyes represents a facile route to synthesize nanoparticles with high drug-loading capability. Here the authors combine a machine learning approach with high-throughput experimental validation to identify which combinations of drugs and excipient lead to successful nanoparticle formation and characterize the therapeutic efficacy of two of them in vitro and in animal models.

Daniel Reker
Yulia Rybakova
Giovanni Traverso
Research25 Mar 2021
Nature Nanotechnology

Volume: 16, P: 725-733
Inhibition of lipoprotein-associated phospholipase A₂ reduces complex coronary atherosclerotic plaque development

Although increased levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) have been associated with cardiac disease, whether this enzyme has a causal role in the development of atherosclerosis has not been clear. Wilensky et al. now show in a pig model of atherosclerosis that a selective Lp-PLA2 inhibitor reduces progression to complex atherosclerotic lesion formation, an effect that is associated with decreased infiltration of inflammatory cells into the lesions. These results support the use of Lp-PLA2 inhibitors for the treatment of atherosclerotic cardiovascular disease.

Robert L Wilensky
Yi Shi
Colin H Macphee
Research21 Sept 2008
Nature Medicine

Volume: 14, P: 1059-1066
Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging

Sensitive and label-free imaging methods to visualize nerve degeneration are currently lacking. Here authors show that stimulated Raman scattering (SRS) microscopy can be used to monitor peripheral nerve degeneration in mouse models of amyotrophic lateral sclerosis (ALS) and in postmortem tissue from ALS patients.

Feng Tian
Wenlong Yang
Kevin Eggan
ResearchOpen Access31 Oct 2016
Nature Communications

Volume: 7, P: 1-15
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
A GR-motif functions in nuclear accumulation of the large FGF-2 isoforms and interferes with mitogenic signalling

Rosanna Dono
Dominic James
Rolf Zeller
Research30 Apr 1998
Oncogene

Volume: 16, P: 2151-2158
Genome-wide association study identifies susceptibility loci for IgA nephropathy

Ali Gharavi, Rick Lifton and colleagues report a genome-wide association study for IgA nephropathy, a major cause of kidney failure. They identify five susceptibility loci.

Ali G Gharavi
Krzysztof Kiryluk
Richard P Lifton
Research13 Mar 2011
Nature Genetics

Volume: 43, P: 321-327
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

Ali Gharavi and colleagues report a genome-wide association analysis of IgA nephropathy in over 20,000 individuals of European and East Asian ancestry. They identify genome-wide significant signals at three new loci near VAV3, CARD9 and ITGAM-ITGAX and correlations between genetic risk and pathogen diversity.

Krzysztof Kiryluk
Yifu Li
Ali G Gharavi
Research12 Oct 2014
Nature Genetics

Volume: 46, P: 1187-1196
A cross-sectional analysis of meteorological factors and SARS-CoV-2 transmission in 409 cities across 26 countries

Possible effects of weather conditions on COVID-19 transmission are debated. Here, the authors analyse data from early in the pandemic and show that although temperature and humidity had small effects on transmission, they were far out-weighed by the effects of non-pharmaceutical interventions.

Francesco Sera
Ben Armstrong
Rachel Lowe
ResearchOpen Access13 Oct 2021
Nature Communications

Volume: 12, P: 1-11
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

Heather J. Cordell
Younghun Han
Katherine A. Siminovitch
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-11
A framework for fibrolamellar carcinoma research and clinical trials

In this Roadmap, Furth, Sethupathy and colleagues discuss advances in our understanding of the mechanisms and treatments of fibrolamellar carcinoma, a rare hepatic cancer that primarily occurs in adolescents and young adults. Recommendations for future progress in research and clinical trials are proposed.

Timothy A. Dinh
Alan F. Utria
Praveen Sethupathy
Reviews21 Feb 2022
Nature Reviews Gastroenterology & Hepatology

Volume: 19, P: 328-342
The tomato genome sequence provides insights into fleshy fruit evolution

This paper reports the genome sequence of domesticated tomato, a major crop plant, and a draft sequence for its closest wild relative; comparative genomics reveal very little divergence between the two genomes but some important differences with the potato genome, another important food crop in the genus Solanum.

Shusei Sato
Satoshi Tabata
René M. Klein Lankhorst
ResearchOpen Access30 May 2012
Nature

Volume: 485, P: 635-641
Nutraceuticals and phytoceuticals in the treatment of schizophrenia: a systematic review and network meta-analysis “Nutra NMA SCZ”

Michele Fornaro
Claudio Caiazza
Marco Solmi
Research18 Jul 2024
Molecular Psychiatry

Volume: 30, P: 168-187
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

Ammar Al-Chalabi, Jan Veldink and colleagues perform a genome-wide association study for amyotrophic lateral sclerosis (ALS) in 15,156 cases and 26,242 controls. They identify three new genome-wide-significant variants and establish ALS as a complex trait with a polygenic architecture, but with a distinct and important role for low-frequency variants.

Wouter van Rheenen
Aleksey Shatunov
Jan H Veldink
Research25 Jul 2016
Nature Genetics

Volume: 48, P: 1043-1048
Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality

Alisia Madè
Simona Greco
Fabio Martelli
ResearchOpen Access21 Nov 2022
Scientific Reports

Volume: 12, P: 1-14
SET_ER/PR: a robust 18-gene predictor for sensitivity to endocrine therapy for metastatic breast cancer

Bruno V. Sinn
Chunxiao Fu
W. Fraser Symmans
ResearchOpen Access30 May 2019
npj Breast Cancer

Volume: 5, P: 1-8
Cell environment shapes TDP-43 function with implications in neuronal and muscle disease

The aetiology of the TDP-43 aggregation manifest itself in the muscle and neuronal cells. Here authors show cell-type characteristic functions of TDP43, reflected in aberrant splicing, likely contributing to disease development.

Urša Šušnjar
Neva Škrabar
Emanuele Buratti
ResearchOpen Access05 Apr 2022
Communications Biology

Volume: 5, P: 1-17
Sex-dependent effects on gut microbiota regulate hepatic carcinogenic outcomes

Guoxiang Xie
Xiaoning Wang
Wei Jia
ResearchOpen Access27 Mar 2017
Scientific Reports

Volume: 7, P: 1-12
Genome-wide characteristics of de novo mutations in autism

Ryan KC Yuen
Daniele Merico
Stephen W Scherer
ResearchOpen Access03 Aug 2016
npj Genomic Medicine

Volume: 1, P: 1-10
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Blocking endothelin-1-receptor/β-catenin circuit sensitizes to chemotherapy in colorectal cancer

Roberta Cianfrocca
Laura Rosanò
Anna Bagnato
ResearchOpen Access14 Jul 2017
Cell Death & Differentiation

Volume: 24, P: 1811-1820
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

Search

Chemosensor receptors are lipid-detecting regulators of macrophage function in cancer

An Asn > Lys substitution in saposin B involving a conserved amino acidic residue and leading to the loss of the single N-glycosylation site in a patient with metachromatic leukodystrophy and normal arylsulphatase A activity

Increased ectodysplasin-A2-receptor EDA2R is a ubiquitous hallmark of aging and mediates parainflammatory responses

Disruption of insulin–like growth factor 2 imprinting in Beckwith–Wiedemann syndrome

Expression of cyclin D1 correlates with malignancy in human ovarian tumours

ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97

Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

Mapping the human genetic architecture of COVID-19

Computationally guided high-throughput design of self-assembling drug nanoparticles

Inhibition of lipoprotein-associated phospholipase A₂ reduces complex coronary atherosclerotic plaque development

Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging

A second update on mapping the human genetic architecture of COVID-19

A GR-motif functions in nuclear accumulation of the large FGF-2 isoforms and interferes with mitogenic signalling

Genome-wide association study identifies susceptibility loci for IgA nephropathy

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

A cross-sectional analysis of meteorological factors and SARS-CoV-2 transmission in 409 cities across 26 countries

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

A framework for fibrolamellar carcinoma research and clinical trials

The tomato genome sequence provides insights into fleshy fruit evolution

Nutraceuticals and phytoceuticals in the treatment of schizophrenia: a systematic review and network meta-analysis “Nutra NMA SCZ”

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality

SET_ER/PR: a robust 18-gene predictor for sensitivity to endocrine therapy for metastatic breast cancer

Cell environment shapes TDP-43 function with implications in neuronal and muscle disease

Sex-dependent effects on gut microbiota regulate hepatic carcinogenic outcomes

Genome-wide characteristics of de novo mutations in autism

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Blocking endothelin-1-receptor/β-catenin circuit sensitizes to chemotherapy in colorectal cancer

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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