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Showing 1–8 of 8 results
Advanced filters: Author: Roscoe Klinck Clear advanced filters

  • Exogenously applied small RNAs have previously been shown to inhibit transcriptional levels when targeted to promoters. They are now shown to alter the ratio of alternative splice forms. The features of splice form alteration are reminiscent of transcriptional gene silencing by siRNAs.

    • Mariano Alló
    • Valeria Buggiano
    • Alberto R Kornblihtt
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 717-724

  • MBNL and FOX splicing factors are known to have a role in the differentiation of muscle and the nervous system during development. In this study, the authors show that MBNL1 and RBFOX2 regulate alternative splicing of genes that are required specifically for late mesoderm differentiation.

    • Julian P. Venables
    • Laure Lapasset
    • Jamal Tazi
    Research
    Nature Communications
    Volume: 4, P: 1-10

  • RNA binding proteins are key regulators of alternative splicing. Here, Best et al. show that the human Tra2α and Tra2ß RNA binding proteins jointly contribute to the control of constitutive and alternative splicing events to regulate essential biological processes including the response to DNA damage.

    • Andrew Best
    • Katherine James
    • David J. Elliott
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-15

  • Although splice isoforms have been observed to change in cancerous cells, the effect of these changes has not always been clear. Using antisense technology, cancer-associated isoforms have now been manipulated in cell lines. The results indicate that shifting splicing patterns of SYK can contribute to cell-cycle changes and anchorage-independent growth and that this change is also triggered by EGF signaling.

    • Panagiotis Prinos
    • Daniel Garneau
    • Sherif Abou Elela
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 673-679

  • A large-scale screen for changes in alternative splice forms in cancer now reveals that almost half of the active alternative splicing events are shifted in breast and ovarian cancer tissues. In addition, many of these changes occur near consensus binding sequences for FOX2 binding sites. This correlates with changes in Fox2 expression or splicing in tissues assessed, and FOX2 depletion results in similar shifts in splice isoforms.

    • Julian P Venables
    • Roscoe Klinck
    • Sherif Abou Elela
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 670-676