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Showing 1–5 of 5 results
Advanced filters: Author: Rosie K. A. Bunton-Stasyshyn Clear advanced filters

  • This article describes the promising technologies for generating humanized mouse models — that is, mouse strains containing large sections of human coding and non-coding sequences — for the purposes of improving our understanding of basic genome function and disease and discovering effective therapies.

    • Anny Devoy
    • Rosie K. A. Bunton-Stasyshyn
    • Elizabeth M. C. Fisher
    Reviews
    Nature Reviews Genetics
    Volume: 13, P: 14-20

  • In a multicenter research program coordinated by the International Mouse Phenotyping Consortium, Spielmann et al. analyze the cardiac function and structure in ~4,000 monogenic mutant mice and identify 705 mouse genes involved in cardiac function, 75% of which have not been previously linked to cardiac heritable disease in humans. Using the UK Biobank human data, the authors validate the link between cardiovascular disease and some of the newly identified genes to illustrate the resource value and potential of their mutant mouse collection.

    • Nadine Spielmann
    • Gregor Miller
    • Martin Hrabe de Angelis
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 1, P: 157-173

  • Reproducibility is key to all fields of research, and in the case of animal research, this can be hampered by inconsistent reporting of animal genetics. Here the authors propose a reporting framework and guidelines designed to discuss the validation and standardise the reporting of genetic backgrounds and genetic alterations in animal models.

    • Lydia Teboul
    • James Amos-Landgraf
    • Guillaume Pavlovic
    ReviewsOpen Access
    Nature Communications
    Volume: 15, P: 1-8

  • A recent article by El-Brolosy and colleagues introduced an unexpected twist for our understanding of knock-out mutations by revealing compensatory mechanisms that recruit the expression of other genes to mitigate the consequences of the mutation. We discuss the main findings of the paper and their impact for our interpretations of the effects of mutations in laboratory animals and humans.

    • Rosie K. A. Bunton-Stasyshyn
    • Sara Wells
    • Lydia Teboul
    Comments & Opinion
    Lab Animal
    Volume: 48, P: 282-284