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Showing 1–3 of 3 results
Advanced filters: Author: Rossella Rispoli Clear advanced filters

  • HSCs emerge from haemogenic endothelium (HE) in the dorsal aorta but whether these tissues share a common lineage is unclear. Here, the authors use a zebrafish runx1 reporter to show that HE maintains an arterial gene expression profile in the absence of Runx1, suggesting the aortic endothelium as a precursor of HE.

    • Florian Bonkhofer
    • Rossella Rispoli
    • Roger Patient
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • How vegfa expression is transcriptionally regulated in vivo is unclear. Here, the authors demonstrate that the ETS transcription factor Etv6 acts as a repressor and an activator of two direct regulators of vegfa expression (foxo3 and klf4, respectively) to control blood formation in Xenopus.

    • Lei Li
    • Rossella Rispoli
    • Catherine Porcher
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Dobrzycki et al delete a conserved enhancer that drives endothelial expression of the transcription factor Gata2a in Zebrafish and find that it is required for programming of haemogenic endothelium and for maintenance of haematopoietic stem cells in the adult. These data may help understanding Gata2 deficiency syndromes in humans.

    • Tomasz Dobrzycki
    • Christopher B. Mahony
    • Rui Monteiro
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-14