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Advanced filters: Author: Rowena Callis Clear advanced filters

  • Structural insights demonstrating small-molecule-mediated dimerization of BRD4 bromodomains led to the development of biBET, a compound that potently inhibits BRD4–acetyl-lysine interactions by bivalent binding to tandem bromodomains.

    • Michael J Waring
    • Huawei Chen
    • Yi Yao
    Research
    Nature Chemical Biology
    Volume: 12, P: 1097-1104