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Showing 1–3 of 3 results
Advanced filters: Author: Rowena L. Lock Clear advanced filters

  • Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediates multidrug resistance, but its natural function remains unclear. Here, Shafik et al. show that PfCRT transports host-derived peptides of 4-11 residues but not other ions or metabolites, and that drug-resistance-conferring PfCRT mutants have reduced peptide transport.

    • Sarah H. Shafik
    • Simon A. Cobbold
    • Rowena E. Martin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • In recent years, the prevalence of multidrug-resistant bacteria has grown considerably, exacerbated by the limited discovery of novel classes of antibacterial agents. Here, Lock and Harry discuss the therapeutic potential of inhibiting bacterial cell division, highlight specific cell-division proteins representing likely antimicrobial targets, and review the recent progress in this exciting new field.

    • Rowena L. Lock
    • Elizabeth J. Harry
    Reviews
    Nature Reviews Drug Discovery
    Volume: 7, P: 324-338

  • Converting somatic cells to induced pluripotent stem cells is becoming routine, but how much do we know about the mechanism of reprogramming? This Review discusses the epigenetic and transcriptional changes that occur and experimental strategies to probe this cell-fate switch.

    • Kathrin Plath
    • William E. Lowry
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 253-265