Benjamin Cheyette and colleagues show that mouse Dact1 mutants have posterior malformations arising from impaired morphogenesis of the primitive streak. Their findings suggest a critical role for Dact1 in regulating cell adhesion at the primitive streak by altering levels or distribution of Vangl2 protein at the plasma membrane.
- Rowena Suriben
- Saul Kivimäe
- Benjamin N R Cheyette
