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Showing 1–4 of 4 results
Advanced filters: Author: Ruben D. Garcia-Ordonez Clear advanced filters

  • Central to the lineage commitment of multipotent mesenchymal stem cells is the nuclear receptor PPARγ, the master regulator of adipogenesis. Here the authors use a variety of structural approaches to rationally design PPARγ inverse agonist SR2595, and demonstrate its ability to promote osteogenesis.

    • David P. Marciano
    • Dana S. Kuruvilla
    • Patrick R. Griffin
    Research
    Nature Communications
    Volume: 6, P: 1-7

  • RIG-I is a critical receptor in the induction of innate immune responses, but mutations in RIG-I can be associated with hyperactive signalling and autoimmune disease. Here Zheng et al. apply HDX-MS approaches to reveal dysregulated checkpoints that result in recognition of self-derived RNA during RIG-I mediated autoimmunity.

    • Jie Zheng
    • Chen Wang
    • Patrick R. Griffin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • The vitamin D receptor/retinoid X receptor-α heterodimer (VDRRXRα) regulates bone mineralization. Here the authors employ hydrogen/deuterium exchange (HDX) mass spectrometry to study the conformational dynamics of VDRRXRα and give mechanistic insights into how VDRRXRα controls the transcriptional activity of specific genes.

    • Jie Zheng
    • Mi Ra Chang
    • Patrick R. Griffin
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • A comprehensive HDX analysis of the vitamin D receptor–retinoid X receptor (VDR-RXR) reveals extensive allosteric communication within the same polypeptide where DNA or ligand can induce alterations in distant domains of the receptors. The work also shows communication between subunits in the heterodimer.

    • Jun Zhang
    • Michael J Chalmers
    • Patrick R Griffin
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 556-563