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Showing 1–3 of 3 results
Advanced filters: Author: Ruby Lieshout Clear advanced filters

  • Tumor organoids derived from the most common subtypes of primary liver cancer recapitulate the histologic and molecular features of the tissues of origin, even after long-term culture. These in vitro models, as well as those for colorectal cancer reported in Crespo et al. in a previous issue, are amenable for drug screening and allow the identification of therapeutic approaches with potential for cancer treatment.

    • Laura Broutier
    • Gianmarco Mastrogiovanni
    • Meritxell Huch
    Research
    Nature Medicine
    Volume: 23, P: 1424-1435

  • Nguyen et al. used liver organoid cultures to identify all somatic mutations in individual stem cells from patients with common liver diseases that confer risk of cancer. The authors report that, compared to healthy liver, these precancerous liver diseases do not result in a detectable increase of mutations, nor an alteration of mutation types in individual liver stem cells.

    • Luan Nguyen
    • Myrthe Jager
    • Ewart Kuijk
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-9