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Showing 1–3 of 3 results
Advanced filters: Author: Rudresh Acharya Clear advanced filters

  • Self-assembly enables complex structures to be fabricated from a few relatively simple components, but requires a detailed understanding of how the constituents may interact. Here, the authors report the rational assembly and crystallographic characterization of a fullerene-protein superstructure.

    • Kook-Han Kim
    • Dong-Kyun Ko
    • Gevorg Grigoryan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • A vital component of influenza A virus' replication machinery is the M2 proton channel. Until recently, M2 was effectively targeted by amantadane-based antivirals, but resistance to these drugs is now so widespread that they have become ineffective. In the second of two related manuscripts, the crystal structure of a 25-residue fragment of M2, both with and without amantadine, is described. It is concluded that a single amantadine molecule binds in the centre of the M2 tetramer to physically occlude the pore.

    • Amanda L. Stouffer
    • Rudresh Acharya
    • William F. DeGrado
    Research
    Nature
    Volume: 451, P: 596-599