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Showing 1–3 of 3 results
Advanced filters: Author: Ruiqian Bu Clear advanced filters

  • Human multidrug resistance protein 5 (hMRP5) effluxes anticancer and antivirus drugs, driving multidrug resistance. Here, the authors present cryo-EM structures of hMRP5 in different states, showing that hMRP5 can be autoinhibited by a short peptide from its N-terminal tail, which prevents the entry of substrates into hMRP5’s transport pathway.

    • Ying Huang
    • Chenyang Xue
    • Zhongmin Liu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • ATP13A2 is a lysosomal polyamine transporter, mutated in several diseases including juvenile-onset Parkinson’s disease. Here, the authors report structures of human ATP13A2 in six distinct intermediate states, illustrating most of its conformational cycle.

    • Jianqiang Mu
    • Chenyang Xue
    • Zhongmin Liu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Cryo-EM structures, MD simulations, and biochemical assays of human multidrug resistance-associated protein 4 in apo inward-open, ATP-bound outward-open, PGE1 substrate-bound, and sulindac inhibitor-bound states provide insights into substrate transport and inhibition mechanism.

    • Ying Huang
    • Chenyang Xue
    • Zhongmin Liu
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-11