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Mitigating the missing-fragmentation problem in de novo peptide sequencing with a two-stage graph-based deep learning model

Identifying unknown peptides in tandem mass spectrometry is challenging as fragmentation of precursor peptides can be incomplete. Mao and colleagues present a method based on graph neural networks and a path-searching model to create more stable sequence predictions.

Zeping Mao
Ruixue Zhang
Ming Li
Research19 Oct 2023
Nature Machine Intelligence

Volume: 5, P: 1250-1260
Synthetic libraries of immune cells displaying a diverse repertoire of chimaeric antigen receptors as a potent cancer immunotherapy

Synthetically generated and clonally expanded libraries of immune cells displaying diverse repertoires of chimaeric antigen receptors lead to long-lasting and potent antitumour responses in mouse models of epithelial tumours.

Wenyan Fu
Changhai Lei
Shi Hu
Research06 Jun 2022
Nature Biomedical Engineering

Volume: 6, P: 842-854
Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice

Calcium/calmodulin-dependent protein kinase IV (CaMK4) has been shown to be involved in autoimmunity but it is not clear how it functions in psoriasis. Here the authors show that CaMK4 is increased in psoriasis and promotes inflammatory responses in mouse models of psoriasis mediated through macrophages and keratinocytes.

Liang Yong
Yafen Yu
Liangdan Sun
ResearchOpen Access22 Jul 2022
Nature Communications

Volume: 13, P: 1-16
Highly efficient ethylene production via electrocatalytic hydrogenation of acetylene under mild conditions

This work achieves highly active and selective electrocatalytic hydrogenation of acetylene to ethylene (HAE) under mild conditions over Cu catalyst to replace the classic thermocatalytic HAE route requiring harsh conditions and costly H₂.

Suheng Wang
Kelechi Uwakwe
Dehui Deng
ResearchOpen Access06 Dec 2021
Nature Communications

Volume: 12, P: 1-9

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Mitigating the missing-fragmentation problem in de novo peptide sequencing with a two-stage graph-based deep learning model

Synthetic libraries of immune cells displaying a diverse repertoire of chimaeric antigen receptors as a potent cancer immunotherapy

Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice

Highly efficient ethylene production via electrocatalytic hydrogenation of acetylene under mild conditions

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