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Advanced filters: Author: Runling Zhang Clear advanced filters

Directed natural evolution generates a next-generation oncolytic virus with a high potency and safety profile

Compromised killing effects of oncolytic viruses due to attenuation of virulence remains a challenge. Here, the authors use a directed natural evolution approach to increase the oncolytic effect of the oncolytic virus M1 attributed to mutations in the E2 and nsP3 genes.

Li Guo
Cheng Hu
Yuan Lin
ResearchOpen Access09 Jun 2023
Nature Communications

Volume: 14, P: 1-15
Identification of the receptor of oncolytic virus M1 as a therapeutic predictor for multiple solid tumors

Deli Song
Xudong Jia
Jing Cai
ResearchOpen Access08 Apr 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-11
CircMTO1 suppresses hepatocellular carcinoma progression via the miR-541-5p/ZIC1 axis by regulating Wnt/β-catenin signaling pathway and epithelial-to-mesenchymal transition

Dandan Li
Jiawei Zhang
Rui Zhang
ResearchOpen Access20 Dec 2021
Cell Death & Disease

Volume: 13, P: 1-13
STT3A-mediated viral N-glycosylation underlies the tumor selectivity of oncolytic virus M1

Deli Song
Xudong Jia
Yuan Lin
Research20 Oct 2023
Oncogene

Volume: 42, P: 3575-3588
Lysates of Lactobacillus acidophilus combined with CTLA-4-blocking antibodies enhance antitumor immunity in a mouse colon cancer model

Qian Zhuo
Bohai Yu
Shuli Zhao
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-12