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Signal Transduction and Targeted Therapy (1)
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Advanced filters: Author: Rusen Lu Clear advanced filters

Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing

Chromosomal structural variations induced by CRISPR/Cas hinder its application in clinics. Here, the authors fuse Cas9 with optimized TREX2 to generate Cas9TX, which can prevent perfect repair and inhibit repeated cleavage.

Jianhang Yin
Rusen Lu
Jiazhi Hu
ResearchOpen Access08 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Efficacy and safety of KN026, a bispecific anti-HER2 antibody, in combination with KN046, an anti-CTLA4/PD-L1 antibody, in patients with advanced HER2-positive nonbreast cancer: a combined analysis of a phase Ib and a phase II study

Dan Liu
Jifang Gong
Lin Shen
ResearchOpen Access19 Mar 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-10

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Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing

Efficacy and safety of KN026, a bispecific anti-HER2 antibody, in combination with KN046, an anti-CTLA4/PD-L1 antibody, in patients with advanced HER2-positive nonbreast cancer: a combined analysis of a phase Ib and a phase II study

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