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Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

Unlike human teeth, mouse incisors grow throughout life, based on stem and progenitor cell activity. Here the authors generate single cell RNA-seq comparative maps of continuously-growing mouse incisor, non-growing mouse molar and human teeth, combined with lineage tracing to reveal dental cell complexity.

Jan Krivanek
Ruslan A. Soldatov
Igor Adameyko
ResearchOpen Access23 Sept 2020
Nature Communications

Volume: 11, P: 1-18
Cell segmentation in imaging-based spatial transcriptomics

Baysor enables cell segmentation based on transcripts detected by multiplexed FISH or in situ sequencing.

Viktor Petukhov
Rosalind J. Xu
Peter V. Kharchenko
Research14 Oct 2021
Nature Biotechnology

Volume: 40, P: 345-354
Haplotype-aware analysis of somatic copy number variations from single-cell transcriptomes

Numbat integrates expression, allele and haplotype information to detect copy number variations in scRNA-seq.

Teng Gao
Ruslan Soldatov
Peter V. Kharchenko
Research26 Sept 2022
Nature Biotechnology

Volume: 41, P: 417-426
RNA velocity of single cells

RNA velocity, estimated in single cells by comparison of spliced and unspliced mRNA, is a good indicator of transcriptome dynamics and will provide a useful tool for analysis of developmental lineage.

Gioele La Manno
Ruslan Soldatov
Peter V. Kharchenko
Research08 Aug 2018
Nature

Volume: 560, P: 494-498
Differential processing of small RNAs during endoplasmic reticulum stress

Mikhail V. Mesitov
Ruslan A. Soldatov
Aleksey A. Moskovtsev
ResearchOpen Access13 Apr 2017
Scientific Reports

Volume: 7, P: 1-14

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Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

Cell segmentation in imaging-based spatial transcriptomics

Haplotype-aware analysis of somatic copy number variations from single-cell transcriptomes

RNA velocity of single cells

Differential processing of small RNAs during endoplasmic reticulum stress

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