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Showing 1–3 of 3 results
Advanced filters: Author: Russell J. Mumper Clear advanced filters

  • Patient drug regime compliance is a major issue; sustained release implants could address this. Here, the authors report on a phase inverted in situ forming implant of PLGA for the sustained release of antiretroviral drugs and optimize and demonstrate the release of 6 different drugs over a period of up to a year.

    • S. Rahima Benhabbour
    • Martina Kovarova
    • J. Victor Garcia
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Long-acting (LA) formulations of antiretroviral (ARV) drugs are an alternative approach to improve adherence for HIV treatment and prevention. Here the authors show a removable biodegradable ultra-LA-ARV drug system that effectively delivers drug, controls viremia and prevents infection in animal models of HIV infection.

    • Martina Kovarova
    • S. Rahima Benhabbour
    • J. Victor Garcia
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • The mucosa of the large intestine mucosa is an effective vaccination site for induction of protective mucosal immunity against rectal or vaginal viral infection but clinically is impractical. Here Qing Zhu et al. have developed an oral delivery system that encapsulates vaccine into pH-dependent poly(DL-lactic-co-glycolic acid) (PLGA) nanoparticles coated with Eudragit to protect against the low pH and enzymatic destruction of the stomach. This approach was shown to selectively target the large intestine in mice and induce antigen-specific T and B cell responses similar to that observed with intracolorectal vaccination.

    • Qing Zhu
    • James Talton
    • Jay A Berzofsky
    Research
    Nature Medicine
    Volume: 18, P: 1291-1296