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Showing 1–4 of 4 results
Advanced filters: Author: Ruth B. McCole Clear advanced filters

  • Homologs are paired in Drosophila somatic cells from embryogenesis to adulthood. Using a computational approach for haplotype-resolved Hi-C, the authors reveal highly structured homolog pairing in Drosophila embryos during zygotic genome activation and demonstrate its application to mammalian embryos.

    • Jelena Erceg
    • Jumana AlHaj Abed
    • C.-ting Wu
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Trans-homolog interactions, such as homolog pairing, are highly structured and associated with gene function in Drosophila cells. Here, the authors use haplotype-resolved Hi-C to identify genome-wide trans-homolog interactions in a Drosophila hybrid cell line and investigate their patterns and functional roles.

    • Jumana AlHaj Abed
    • Jelena Erceg
    • C.-ting Wu
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • The spatial organization of the genome within the nucleus impacts many processes. Here the authors combine oligo-based DNA FISH with single-molecule super-resolution microscopy to image single-copy genomic regions and, taking advantage of SNPs, distinguish allelic regions of homologous chromosomes.

    • Brian J. Beliveau
    • Alistair N. Boettiger
    • Chao-ting Wu
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • Shamil Sunyaev, Alexander Gimelbrant and colleagues report an analysis of the genetic variability in human monoallelically expressed genes. They find that genes with monoallelic expression show greater genetic diversity than biallelically expressed genes and that this diversity is associated with greater allelic age.

    • Virginia Savova
    • Sung Chun
    • Alexander A Gimelbrant
    Research
    Nature Genetics
    Volume: 48, P: 231-237