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Scientific Reports (2)
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Showing 1–4 of 4 results

Advanced filters: Author: Ruth E. Watkinson Clear advanced filters

Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase

In this Article, the authors report the discovery of a small molecule (GHP-88309) that is a new class of allosteric viral polymerase inhibitor that works against two different genera of paramyxoviruses.

Robert M. Cox
Julien Sourimant
Richard K. Plemper
Research13 Jul 2020
Nature Microbiology

Volume: 5, P: 1232-1246
Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21

During pathogen infection, antibodies can be carried into the cell, where they are detected by the cytosolic antibody receptor TRIM21. McEwan and colleagues show that the recognition of intracellular antibodies by TRIM21 activates immunological signaling.

William A McEwan
Jerry C H Tam
Leo C James
Research03 Mar 2013
Nature Immunology

Volume: 14, P: 327-336
Correction: Corrigendum: Antibody-antigen kinetics constrain intracellular humoral immunity

Maria Bottermann
Heidrun Elisabeth Lode
Leo C. James
Amendments and CorrectionsOpen Access06 Apr 2017
Scientific Reports

Volume: 7, P: 1
Antibody-antigen kinetics constrain intracellular humoral immunity

Maria Bottermann
Heidrun Elisabeth Lode
Leo C. James
ResearchOpen Access24 Nov 2016
Scientific Reports

Volume: 6, P: 1-11