RGS5, a signalling protein that regulates the activity of G proteins, is shown to be an important regulator of the tumour vasculature. Deletion of RGS5 leads to normalization of blood vessels of tumours, making them less leady and improving their coverage with pericytes. As a consequence, more immune cells that can target the tumour cells reach the tumour, which enhances the survival of tumour-bearing mice.
- Juliana Hamzah
- Manfred Jugold
- Ruth Ganss
