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Showing 1–3 of 3 results
Advanced filters: Author: Ruth Nduati Clear advanced filters

  • Antibodies capable of neutralizing a broad array of HIV-1 viral isolates from different clades have been isolated from some chronically infected individuals, but their development is thought to require several years. In this issue, Julie Overbaugh and her colleagues report that HIV-infected infants also develop broadly neutralizing antibodies—some at 1 year of age—and their occurrence early in life may shed light on HIV vaccine efforts to induce these antibodies.

    • Leslie Goo
    • Vrasha Chohan
    • Julie Overbaugh
    Research
    Nature Medicine
    Volume: 20, P: 655-658

  • Development of broadly neutralizing antibodies (bnAb) against HIV-1 in infected adults is a multi-step process unachievable by current vaccine approaches. Here the authors reconstruct the ontogeny of an infant bnAb, which develops in fewer steps, and identify its unique features that may shorten the path to HIV vaccines.

    • Cassandra A. Simonich
    • Laura Doepker
    • Julie Overbaugh
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12