Mammalian caspases are a group of cysteine proteases historically categorized into an ‘inflammatory’ subgroup and an ‘apoptotic’ subgroup, although accumulating evidence indicates that this distinction is not as clearcut as initially thought. Here, we discuss the functions of inflammatory caspases and apoptotic caspases, while proposing that all caspases ultimately regulate inflammation, either directly or by controlling cell death.
- Manuel Beltrán-Visiedo
- Ruth Soler-Agesta
- Lorenzo Galluzzi
