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Showing 1–25 of 25 results
Advanced filters: Author: Ryan M. Camacho Clear advanced filters

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • The coherent storage and retrieval of a four-wave-mixing normal mode in a hot atomic rubidium vapour may prove to be useful for future information processing schemes.

    • Ryan M. Camacho
    • Praveen K. Vudyasetu
    • John C. Howell
    Research
    Nature Photonics
    Volume: 3, P: 103-106

  • Nanocavity optomechanical systems can exhibit strong dynamical back-action between mechanical motion and the cavity light field. Here, optical control of mechanical motion within two different nanocavity structures is demonstrated. A form of optically controlled mechanical transparency is also demonstrated, which is analogous to electromagnetically induced transparency.

    • Qiang Lin
    • Jessie Rosenberg
    • Oskar Painter
    Research
    Nature Photonics
    Volume: 4, P: 236-242

  • By bringing together whole exome and genome sequencing data from five cohorts, the authors assess the contribution of rare germline variants to prostate cancer risk and severity, further validating previously reported genes, and implicating a role for genes not previously reported.

    Peer review information

    Nature Communications thanks the anonymous reviewer(s) for their contribution to the peer review of this work. A peer review file is available.

    • Jonathan Mitchell
    • Niedzica Camacho
    • Margarete A. Fabre
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Wood density is a key control on tree biomass, and understanding its spatial variation improves estimates of forest carbon stock. Sullivan et al. measure >900 forest plots to quantify wood density and produce high resolution maps of its variation across South American tropical forests.

    • Martin J. P. Sullivan
    • Oliver L. Phillips
    • Joeri A. Zwerts
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • A set of three papers in Nature reports a new proteomics resource from the UK Biobank and initial analysis of common and rare genetic variant associations with plasma protein levels.

    • Ryan S. Dhindsa
    • Oliver S. Burren
    • Slavé Petrovski
    ResearchOpen Access
    Nature
    Volume: 622, P: 339-347

  • In a photonic crystal, the periodicity of the host medium is used to manipulate the properties of light, whereas in a phononic crystal it is mechanical vibrations that are subject to such control. Here, a structure that acts as both a photonic and phononic crystal — an 'optomechanical' crystal — is described; the strong coupling between photons and phonons realized in this structure should find application in a host of sensing and communication technologies.

    • Matt Eichenfield
    • Jasper Chan
    • Oskar Painter
    Research
    Nature
    Volume: 462, P: 78-82

  • Interfacing spin quantum memories with photons requires the controlled creation of defect centre—nanocavity systems. Here the authors demonstrate direct, maskless creation of single silicon vacancy centres in diamond nanostructures, and report linewidths comparable to naturally occurring centres

    • Tim Schröder
    • Matthew E. Trusheim
    • Dirk Englund
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-7

  • The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

    • G. Aad
    • B. Abbott
    • L. Zwalinski
    ResearchOpen Access
    Nature Communications
    Volume: 2, P: 1-14

  • This Perspective highlights the global consensus on the urgency and growing threat of invasive alien species, and management needs, as found by the 2023 report on invasive alien species conducted by the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES).

    • Helen E. Roy
    • Aníbal Pauchard
    • Sílvia R. Ziller
    Reviews
    Nature Ecology & Evolution
    Volume: 8, P: 1216-1223

  • MSK-IMPACT is a clinical sequencing platform able to detect genomic mutations, copy number alterations and structural variants in a panel of cancer-related genes. This assay is implemented prospectively to inform patient enrollment in genomically matched clinical trials at Memorial Sloan Kettering Cancer Center (MSKCC). Sequencing results of tumor and matched normal tissue from a cohort of >10,000 patients with detailed clinical annotation provide an overview of the genomic landscape of advanced solid cancers and bring new insights into molecularly guided cancer therapy.

    • Ahmet Zehir
    • Ryma Benayed
    • Michael F Berger
    Research
    Nature Medicine
    Volume: 23, P: 703-713

  • NRAS-driven melanomas have limited therapeutic options. Combining genetically engineered models and oncogenic signaling inhibitors with rational systems-biology approaches, the authors compare the effects of genetic extinction of NRAS to that of chemical pathway inhibition targeting downstream MEK. The differences provide actionable targets by revealing that NRAS signaling operates as a gated output and that MEK inhibition, although inducing apoptosis, is not able to achieve further inhibition of NRAS-induced outputs such as cell-cycle progression. A combination of MEK and CDK4 inhibitors provides a more complete inhibition of NRAS signaling and a more effective antitumor effect in vivo.

    • Lawrence N Kwong
    • James C Costello
    • Lynda Chin
    Research
    Nature Medicine
    Volume: 18, P: 1503-1510

  • The fact that photons of light carry momentum and can therefore exert mechanical force is not just an academic curiosity; such forces have already been harnessed for a variety of applications. Here, an extreme optomechanical regime is created using a system of simple photonic structures engineered in such a way that light and mechanical energy are localized in a tiny volume on a silicon chip, so that the mechanical rigidity of the resulting structure is dominated by the optical forces.

    • Matt Eichenfield
    • Ryan Camacho
    • Oskar Painter
    Research
    Nature
    Volume: 459, P: 550-555

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29