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GALNTL5 binds GalNAc and is required for migration through the uterotubal junction and sperm-zona pellucida binding

For fertilization, sperm migrate through the utero-tubal junction (UTJ) and bind to the zona pellucida (ZP). Here the authors identify sperm expressed GALNTL5 as a GalNAc binding factor required for migration though the UTJ and attachment to the ZP.

Taichi Noda
Reika Uriu
Masahito Ikawa
ResearchOpen Access17 Sept 2025
Nature Communications

Volume: 16, P: 1-15

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GALNTL5 binds GalNAc and is required for migration through the uterotubal junction and sperm-zona pellucida binding

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