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Showing 1–13 of 13 results
Advanced filters: Author: Ryan Schreiner Clear advanced filters

  • The pancreatic vasculature displays significant heterogeneity, with the islets perfused by a specialized microcirculation with greater density than the surrounding acinar tissue. Using single-cell RNA sequencing of human pancreases and integration with further data, the authors reveal the vascular transcriptomic heterogeneity in the healthy and diabetic pancreas.

    • Rebecca Craig-Schapiro
    • Ge Li
    • David Redmond
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • The antibody response to COVID-19 vaccines varies among individuals. Here the authors find that older age, male sex, smoking, higher BMI, vaccine type, and certain comorbidities are associated with lower anti-S1 antibody levels after COVID-19 vaccinations, indicating that certain groups might benefit from higher frequency or doses of vaccination.

    • John S. Kim
    • Yifei Sun
    • Elizabeth C. Oelsner
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Epithelial cells sort proteins into apical and basolateral domains. Clathrin plays a key and selective role in the generation of basolateral protein polarity. These results demonstrate an important role of clathrin in sorting of proteins at the trans-Golgi network.

    • Sylvie Deborde
    • Emilie Perret
    • Enrique Rodriguez-Boulan
    Research
    Nature
    Volume: 452, P: 719-723

  • Itkin et al. identify a role for Fli-1 in hematopoietic stem cell activation during regenerative hematopoiesis. They show that Fli-1 coordinates hematopoietic stem cells to stimulate niche-derived Notch1 feedback signals for demand-needed hematopoietic cell output.

    • Tomer Itkin
    • Sean Houghton
    • Shahin Rafii
    Research
    Nature Immunology
    Volume: 26, P: 378-390

  • An increase in the volume of the brain lateral ventricles is a sign of normal aging, but can also be associated with neurological and psychiatric disorders. Here, Vojinovic et al. identify seven genetic loci in a GWA study for ventricular volume in 23,500 individuals and find correlation with thalamus volume.

    • Dina Vojinovic
    • Hieab H. Adams
    • Myriam Fornage
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Gomez-Salinero, Itkin et al. demonstrate the cooperative role of two ETS transcriptor factors, ERG and Fli1, in the active maintenance of endothelial cell homeostatic function. Loss of these two genes in adult mice leads to multi-organ failure, hyperinflammation, systemic thrombosis and death. In vitro, expression of both ERG and FLI1 induces human adult non-vascular mesenchymal stromal cells to acquire endothelial-like properties. In humans, several cardiovascular disorders and inflammatory-related diseases are linked to mutations in both genes.

    • Jesus M. Gomez-Salinero
    • Tomer Itkin
    • Shahin Rafii
    Research
    Nature Cardiovascular Research
    Volume: 1, P: 882-899

  • The transient reactivation of ETV2 in adult human endothelial cells reprograms these cells to become adaptable vasculogenic endothelia that in three-dimensional matrices self-assemble into vascular networks that can transport blood and physiologically arborize organoids and decellularized tissues.

    • Brisa Palikuqi
    • Duc-Huy T. Nguyen
    • Shahin Rafii
    Research
    Nature
    Volume: 585, P: 426-432

  • Basolateral recycling and transcytotic pathways in epithelial cells are defined by specific markers, however the apical recycling pathway is poorly understood. Perez Bay et al. show that Megalin is a marker for this pathway, which intersects with the other routes in shared perinuclear recycling endosomes.

    • Andres E. Perez Bay
    • Ryan Schreiner
    • Enrique J. Rodriguez-Boulan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15

  • Keri Monda, Kari North, Christopher Haiman and colleagues report a meta-analysis of GWAS for body mass index that is composed of 39,144 individuals of African ancestry, followed by further genotyping in 32,268 individuals of African ancestry. The study also includes analysis of publicly available data from the GIANT consortium of ~124,000 individuals of European ancestry. The paper reports evidence for two new loci near GALNT10 and MIR148A.

    • Keri L Monda
    • Gary K Chen
    • Christopher A Haiman
    Research
    Nature Genetics
    Volume: 45, P: 690-696

  • Barcia Durán et al. show that the tyrosine kinase gene Jak3 is expressed in multiple endothelial cell types in the mouse, including in non-hematopoietic organs, with particularly high expression in the bone marrow. Using mice lacking Jak3, they show that Jak3 expressed in the bone marrow niche is important for maintaining long-term repopulating hematopoietic stem cells.

    • José Gabriel Barcia Durán
    • Tyler Lu
    • Raphaël Lis
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-14