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Showing 1–4 of 4 results
Advanced filters: Author: Ryan T. Vanderlinden Clear advanced filters

  • Catenated cages are challenging synthetic targets in chemistry. Here, the authors employ a multi-component coordination strategy using a Pt(II) heteroligation to construct a cyclic bis[2]catenane metallacage, which could be reversibly transformed between the catenated structure and the bis-metallacage.

    • Yiliang Wang
    • Yicheng Zhang
    • Peter J. Stang
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-7

  • The presence of antibodies to citrullinated protein antigens (ACPA) in peripheral blood represents a risk a state that is ‘at-risk’ for subsequent development of rheumatoid arthritis (RA). Here authors compare multiple molecular and immunological parameters in individuals who are ACPA positive without inflammatory arthritis, ACPA negative controls and patients diagnosed with ACPA positive early-stage RA to conclude that complex immunopathological processes are present in an ACPA positive state which may be targeted by future preventive approaches for RA.

    • Eddie A. James
    • V. Michael Holers
    • Kevin D. Deane
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Mass photometry is a label-free optical approach capable of detecting, imaging and accurately measuring the mass of single biomolecules in solution. Here, the authors demonstrate the potential of mass photometry for quantitatively characterizing sample heterogeneity of purified protein complexes with implications for structural studies specifically and in vitro studies more generally.

    • Adar Sonn-Segev
    • Katarina Belacic
    • Philipp Kukura
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10