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Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development

Abnormal CSF accumulation in the brain can lead to hydrocephalus. The mechanisms regulating CSF clearance during early development are unclear. Here, the authors show that NKCC1 regulates the clearance of both CSF K⁺ and fluid volume through the choroid plexus during postnatal development in mice.

Huixin Xu
Ryann M. Fame
Maria K. Lehtinen
ResearchOpen Access19 Jan 2021
Nature Communications

Volume: 12, P: 1-16
Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution

The choroid plexus (ChP) modulates cerebrospinal fluid (CSF) composition and the blood-CSF barrier. Here the authors show that the ChP is a critical circadian component with time-of-day variations in translation, barrier, and metabolism to alter CSF composition.

Ryann M. Fame
Peter N. Kalugin
Maria K. Lehtinen
ResearchOpen Access22 Jun 2023
Nature Communications

Volume: 14, P: 1-20
SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development

The closely related Sox5 and Sox6 turn out to perform distinct functions during brain development. Maintenance of the ventricular zone neuroepithelium requires Sox6 in the dorsal and Sox5 in the ventral telencephalon. A portion of the interneurons born in ventral telencephalon then express Sox6, which is necessary for their correct migration and phenotypic differentiation.

Eiman Azim
Denis Jabaudon
Jeffrey D Macklis
Research05 Aug 2009
Nature Neuroscience

Volume: 12, P: 1238-1247
Harnessing the circadian nature of the choroid plexus and cerebrospinal fluid

Ryann M. Fame
ReviewsOpen Access26 May 2025
npj Biological Timing and Sleep

Volume: 2, P: 1-12
Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development

Qun Li
Zhiyuan Han
Haotian Zhao
ResearchOpen Access23 Mar 2022
Cell Death & Differentiation

Volume: 29, P: 1596-1610

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Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development

Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution

SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development

Harnessing the circadian nature of the choroid plexus and cerebrospinal fluid

Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development

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