Jane Weng et al. show that a MCRIP1, a regulator of the CtBP transcriptional co-repressor, promotes the expression of lung-specific surfactant proteins SP-B and SP-C, which prevent alveolar collapse. They show that MCRIP1 deficiency in mice causes fatal neonatal respiratory disease by inducing epigenetic silencing of SP-B/C.
- Jane S. Weng
- Takanori Nakamura
- Mutsuhiro Takekawa
