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Showing 1–3 of 3 results
Advanced filters: Author: Ryoki Nakamura Clear advanced filters

  • Ryoki Nakamura et al. report the cryo-EM structure of the volume-regulated anion channel LRRC8D isoform, which enables permeation of organic compounds into cells. Compared to the LRRC8A isoform, the LRRC8D isoform has a wider extracellular pore and an intracellular N-terminal helix that may function in gating.

    • Ryoki Nakamura
    • Tomohiro Numata
    • Osamu Nureki
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-10

  • Cryo-EM analyses of human LRRC8A show a homohexameric assembly that can adopt two conformations, compact or relaxed, indicating rigid-body motions that might be involved in channel gating.

    • Go Kasuya
    • Takanori Nakane
    • Osamu Nureki
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 797-804

  • P2X receptors are nonselective cation channels that are gated by extracellular ATP. Here the authors present the crystal structure of chicken P2X7 with its bound competitive antagonist TNP-ATP and give mechanistic insights into TNP-ATP dependent inhibition through further computational analysis and electrophysiology measurements.

    • Go Kasuya
    • Toshiaki Yamaura
    • Osamu Nureki
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10