Nature Search

Response to: Do angiotensin-converting enzyme inhibitors not reduce the risk of pneumonia?

Ryosuke Uemura
Haruhisa Fukuda
Correspondence06 Oct 2025
Hypertension Research

P: 1-2
Selective-plane-activation structured illumination microscopy

The combination of light sheet illumination and reversibly switchable fluorophores enables improved structured illumination microscopy for fast, low-background super-resolution imaging in cells and spheroids.

Kenta Temma
Ryosuke Oketani
Katsumasa Fujita
Research05 Apr 2024
Nature Methods

Volume: 21, P: 889-896
Risk of pneumonia-related hospitalization after initiating angiotensin-converting enzyme inhibitors compared with angiotensin II receptor blockers: a retrospective cohort study using LIFE Study data

We conducted a large-scale retrospective cohort study using real-world healthcare data from a Japanese population. In this study, ACEI initiation did not indicate a significant preventive effect against pneumonia-related hospitalization.

Ryosuke Uemura
Michinari Hieda
Haruhisa Fukuda
Research28 Jun 2024
Hypertension Research

Volume: 47, P: 2275-2283
Microtubule-associated phase separation of MIDD1 tunes cell wall spacing in xylem vessels in Arabidopsis thaliana

The microtubule-associated protein MIDD1 fine-tunes the secondary cell wall patterns in xylem vessels by forming co-condensates with KINESIN-13A, which induces the massive catastrophe of microtubules, in Arabidopsis thaliana.

Takeshi Higa
Saku T. Kijima
Yoshihisa Oda
Research03 Jan 2024
Nature Plants

Volume: 10, P: 100-117
Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity

Kenichiro Nagai
Keisuke Kobayashi
Hiroshi Tomoda
Research24 Jan 2024
The Journal of Antibiotics

Volume: 77, P: 214-220
Triple nitrogen-vacancy centre fabrication by C₅N₄H_n ion implantation

There is an extensive literature discussing the potential applications of individual nitrogen vacancy centres but some proposed developments require the use of multiple, coupled defects. Here the authors demonstrate a method to fabricate coupled nitrogen vacancy centre triplets.

Moriyoshi Haruyama
Shinobu Onoda
Osamu Hanaizumi
ResearchOpen Access13 Jun 2019
Nature Communications

Volume: 10, P: 1-9
Comparison of the inhibitory effect of tocilizumab and etanercept on the progression of joint erosion in rheumatoid arthritis treatment

Shinya Hayashi
Tsukasa Matsubara
Ryosuke Kuroda
ResearchOpen Access20 Oct 2022
Scientific Reports

Volume: 12, P: 1-7
Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water

Yuki Maruyama
Yuichiro Nishimoto
Shinji Fukuda
ResearchOpen Access13 Jan 2022
Scientific Reports

Volume: 12, P: 1-9
Association between MR-proADM concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control

Motoshi Iwao
Ryota Tanaka
Hiroki Itoh
ResearchOpen Access09 Nov 2021
Scientific Reports

Volume: 11, P: 1-9
Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell

The F508 deletion (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) is the most common CF causing mutation. Here the authors show that cytosolic chaperones shift the F508del channel conformation to the native fold by kinetic and thermodynamic remodelling of the gating energetics towards that of wild-type CTFR.

Miklos Bagdany
Guido Veit
Gergely L. Lukacs
ResearchOpen Access30 Aug 2017
Nature Communications

Volume: 8, P: 1-15
Concept, study design, and baseline nighttime blood pressure control status of the WISDOM–Night Study using a wrist-type oscillometric home blood pressure monitoring device

Kazuomi Kario
Naoko Tomitani
Satoshi Hoshide
Research12 Oct 2024
Hypertension Research

Volume: 48, P: 592-603
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism

Endoplasmic reticulum (ER) stress has been proposed to play a role in metabolic diseases. Here, Sasako and colleagues identify stromal cell-derived factor 2 like 1 (Sdf2l1) as a regulator of the ER stress response to feeding in the liver, and suggest that its downregulation may promote diabetes and hepatic steatosis in humans.

Takayoshi Sasako
Mitsuru Ohsugi
Kohjiro Ueki
ResearchOpen Access27 Feb 2019
Nature Communications

Volume: 10, P: 1-16
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

Yoshiya Kawaguchi and colleagues show that a Sox9-positive progenitor pool located in the epithelia of the biliary and pancreatic ducts of adult mice serves as a continuous source of intestinal cells, hepatocytes and pancreatic acinar cells, identifying a shared pathway underlying the cellular renewal of these adult endodermal organs.

Kenichiro Furuyama
Yoshiya Kawaguchi
Shinji Uemoto
Research28 Nov 2010
Nature Genetics

Volume: 43, P: 34-41
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
The APOA1 p.Leu202Arg variant potentially causes autosomal recessive cardiac amyloidosis

Shusuke Yagi
Ryosuke Miyamoto
Masataka Sata
ResearchOpen Access16 Aug 2024
Human Genome Variation

Volume: 11, P: 1-4
Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21

Highly concentrated trehalose induces beneficial senescence-like state in fibroblasts and accelerates the proliferation of keratinocytes and angiogenesis to promote optimal wound repair, demonstrating its therapeutic potential in modulating fibroblast functions.

Jun Muto
Shinji Fukuda
Koji Sayama
ResearchOpen Access06 Jan 2023
Communications Biology

Volume: 6, P: 1-18
Clinical and molecular investigation of 14 Japanese patients with complete TFP deficiency: a comparison with Caucasian cases

Ryosuke Bo
Kenji Yamada
Seiji Yamaguchi
Research18 May 2017
Journal of Human Genetics

Volume: 62, P: 809-814
Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis

Takeshi Wada
Kazuma Yamakawa
Satoshi Gando
ResearchOpen Access03 Jun 2022
Scientific Reports

Volume: 12, P: 1-10
Treatment strategy changes for inflammatory bowel diseases in biologic era: results from a multicenter cohort in Japan, Far East 1000

Takashi Taida
Yuki Ohta
Naoya Kato
ResearchOpen Access21 Aug 2023
Scientific Reports

Volume: 13, P: 1-11
Individual HLAs influence immunological events in allogeneic stem cell transplantation from HLA-identical sibling donors

Satoko Morishima
Takahiro Fukuda
Kento Umino
Research09 Oct 2020
Bone Marrow Transplantation

Volume: 56, P: 646-654
Predictive factors for effective selection of Interleukin-6 inhibitor and tumor necrosis factor inhibitor in the treatment of rheumatoid arthritis

Shinya Hayashi
Tsukasa Matsubara
Ryosuke Kuroda
ResearchOpen Access06 Oct 2020
Scientific Reports

Volume: 10, P: 1-8
Susceptibility of cyclin-dependent kinase inhibitor 1-deficient mice to rheumatoid arthritis arising from interleukin-1β-induced inflammation

Yoshinori Takashima
Shinya Hayashi
Ryosuke Kuroda
ResearchOpen Access15 Jun 2021
Scientific Reports

Volume: 11, P: 1-15
Impact of the combination of donor age and HLA disparity on the outcomes of unrelated bone marrow transplantation

Sachiko Seo
Yoshiaki Usui
Fumiya Wada
Research14 May 2021
Bone Marrow Transplantation

Volume: 56, P: 2410-2422
Comprehensive renoprotective effects of ipragliflozin on early diabetic nephropathy in mice

Michitsugu Kamezaki
Tetsuro Kusaba
Keiichi Tamagaki
ResearchOpen Access05 Mar 2018
Scientific Reports

Volume: 8, P: 1-14
Comparison of reduced-intensity/toxicity conditioning regimens for umbilical cord blood transplantation for lymphoid malignancies

Nobuhiko Imahashi
Seitaro Terakura
Takaya Mitsuyoshi
Research21 May 2020
Bone Marrow Transplantation

Volume: 55, P: 2098-2108
Carotid plaque score and intima media thickness as predictors of stroke and mortality in hypertensive patients

Tatsuo Kawai
Mitsuru Ohishi
Hiromi Rakugi
Research04 Jul 2013
Hypertension Research

Volume: 36, P: 902-909
Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients

Takeshi Wada
Atsushi Shiraishi
Yasuhiro Otomo
ResearchOpen Access26 May 2021
Scientific Reports

Volume: 11, P: 1-12
Impact of center volume on in-hospital mortality in adult patients with out‑of‑hospital cardiac arrest resuscitated using extracorporeal cardiopulmonary resuscitation: a secondary analysis of the SAVE-J II study

Kayo Misumi
Yoshihiro Hagiwara
Hideto Yokoi
ResearchOpen Access09 Apr 2024
Scientific Reports

Volume: 14, P: 1-8
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study

Yukari Yada
Akihide Ohkuchi
Mariko Hida
ResearchOpen Access08 May 2020
Scientific Reports

Volume: 10, P: 1-13

Search

Response to: Do angiotensin-converting enzyme inhibitors not reduce the risk of pneumonia?

Selective-plane-activation structured illumination microscopy

Risk of pneumonia-related hospitalization after initiating angiotensin-converting enzyme inhibitors compared with angiotensin II receptor blockers: a retrospective cohort study using LIFE Study data

Microtubule-associated phase separation of MIDD1 tunes cell wall spacing in xylem vessels in Arabidopsis thaliana

Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity

Triple nitrogen-vacancy centre fabrication by C₅N₄H_n ion implantation

Comparison of the inhibitory effect of tocilizumab and etanercept on the progression of joint erosion in rheumatoid arthritis treatment

Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water

Association between MR-proADM concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell

Concept, study design, and baseline nighttime blood pressure control status of the WISDOM–Night Study using a wrist-type oscillometric home blood pressure monitoring device

Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

The APOA1 p.Leu202Arg variant potentially causes autosomal recessive cardiac amyloidosis

Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21

Clinical and molecular investigation of 14 Japanese patients with complete TFP deficiency: a comparison with Caucasian cases

Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis

Treatment strategy changes for inflammatory bowel diseases in biologic era: results from a multicenter cohort in Japan, Far East 1000

Individual HLAs influence immunological events in allogeneic stem cell transplantation from HLA-identical sibling donors

Predictive factors for effective selection of Interleukin-6 inhibitor and tumor necrosis factor inhibitor in the treatment of rheumatoid arthritis

Susceptibility of cyclin-dependent kinase inhibitor 1-deficient mice to rheumatoid arthritis arising from interleukin-1β-induced inflammation

Impact of the combination of donor age and HLA disparity on the outcomes of unrelated bone marrow transplantation

Comprehensive renoprotective effects of ipragliflozin on early diabetic nephropathy in mice

Comparison of reduced-intensity/toxicity conditioning regimens for umbilical cord blood transplantation for lymphoid malignancies

Carotid plaque score and intima media thickness as predictors of stroke and mortality in hypertensive patients

Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients

Impact of center volume on in-hospital mortality in adult patients with out‑of‑hospital cardiac arrest resuscitated using extracorporeal cardiopulmonary resuscitation: a secondary analysis of the SAVE-J II study

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study

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