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Showing 1–7 of 7 results
Advanced filters: Author: Ryoya Nakagawa Clear advanced filters
  • Cryo-electron microscopy structures of the prime editor bound to a prime editing guide RNA and target DNA, in the pre-initiation, initiation and elongation and termination states, provide insights into the mechanism by which prime editing occurs.

    • Yutaro Shuto
    • Ryoya Nakagawa
    • Osamu Nureki
    ResearchOpen Access
    Nature
    Volume: 631, P: 224-231
  • Cryo-electron microscopy analysis of the Deinococcus radiodurans ISDra2 TnpB in complex with its cognate ωRNA and target DNA provides insights into the mechanism of TnpB function and the evolution of CRISPR–Cas12 effectors.

    • Ryoya Nakagawa
    • Hisato Hirano
    • Osamu Nureki
    ResearchOpen Access
    Nature
    Volume: 616, P: 390-397
  • Here, the authors structurally decipher how Cas12m2 protects against mobile genetic elements by tightly binding invading DNA via a unique arginine-rich cluster and its non-canonical RuvC site.

    • Satoshi N. Omura
    • Ryoya Nakagawa
    • Osamu Nureki
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 1172-1182
  • SpCas9 is a versatile genome-editing tool, but it is large and cannot be packaged efficiently in a AAV vector, limiting its application. The reported engineered Campylobacter jejuni Cas9 variant exhibits enhanced cleavage activity and a broader targeting range, expanding the CRISPR-Cas toolbox for therapeutic genome engineering.

    • Ryoya Nakagawa
    • Soh Ishiguro
    • Osamu Nureki
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-8
  • A crystal structure of Brevibacillus laterosporus Cas9 highlights the mechanistic diversity among the CRISPR-Cas9 effector enzymes.

    • Toshihiro Nakane
    • Ryoya Nakagawa
    • Osamu Nureki
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-10
  • The authors develop a platform (SATORI) that enables accurate and rapid detection of single-stranded RNA at a single-molecule level without a pre-amplification step. As a proof-of-concept, they demonstrate its utility in detecting the SARS-CoV-2 N gene at a minimum concentration of ~5 fM, which is much lower than other amplification-free CRISPR-Cas-based methods.

    • Hajime Shinoda
    • Yuya Taguchi
    • Rikiya Watanabe
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-7