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Showing 1–9 of 9 results
Advanced filters: Author: Ryuichiro Hirano Clear advanced filters

  • Ecto-nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) is a type II transmembrane glycoprotein that hydrolyzes both ATP and cGAMP. Here the authors present the crystal structures of the extracellular domain of mouse ENPP1 in complex with 3′3′-cGAMP and the reaction intermediate pA(3′,5′)pG and discuss mechanistic implications.

    • Kazuki Kato
    • Hiroshi Nishimasu
    • Osamu Nureki
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8

  • In Arabidopsis, LZY proteins are involved in specifying the angle of root growth relative to the direction of gravity. Here the authors identify RLD1, a LZY-interacting protein that is recruited to the plasma membrane in a polar manner and is required to establish asymmetric auxin transport and set root angles.

    • Masahiko Furutani
    • Yoshinori Hirano
    • Miyo Terao Morita
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • The RNA-guided DNA endonuclease Cas9 from Corynebacterium diphtheriae (CdCas9) recognizes a promiscuous protospacer adjacent motif (PAM). Here the authors provide insights into the CdCas9-mediated PAM recognition mechanism by determining the 2.9 Å crystal structure of CdCas9 in complex with the guide RNA and its target DNA, which is of interest for engineering of CRISPR-Cas9 genome-editor nucleases.

    • Seiichi Hirano
    • Omar O. Abudayyeh
    • Osamu Nureki
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Vacuolar iron transporter 1 (VIT1) is important for iron homeostasis in plants. VIT1 forms a dimeric structure with five membrane-spanning domains, and an ion-translocating pathway of methionine and carboxylate residues at the dimer interface.

    • Takafumi Kato
    • Kaoru Kumazaki
    • Osamu Nureki
    Research
    Nature Plants
    Volume: 5, P: 308-315

  • PIWI-clade Argonautes bind PIWI-interacting RNAs (piRNAs) to silence transposons and maintain genome integrity in animal gonads. Here the authors present the crystal structure of a Drosophila Piwi–piRNA complex isolated from cultured fly ovarian somatic cells and find that it contains a non-canonical DVDK tetrad, and lacks slicer activity in vitro.

    • Sonomi Yamaguchi
    • Akira Oe
    • Osamu Nureki
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Chromosome condensation is a prerequisite for faithful segregation of chromosomes to daughter cells. Here, the authors show that the condensin complex binds to protein-coding genes in a transcription-dependent manner during condensation, and reduces unwound DNA segments generated by transcription.

    • Takashi Sutani
    • Toyonori Sakata
    • Katsuhiko Shirahige
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13